K.V. Waynant Research Group

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Waynant Group Research

Organic Synthesis

The group has multiple synthesis projects as Prof. Waynant begins his independent career.  Most of the project center on target driven glycosides and other biologically important natural products as well as ligand development for metal catalysts.

Polymeric Materials

The group also focuses on new polymeric materials as well as the building of stimuli-responsive and stimuli-reactive polymeric surfaces as well as polymer brush derived sensors. 

ASAP Publications

Journal of Chemical Education, Article ASAP
DOI: 10.1021/acs.jchemed.7b00969
Publication Date (Web): May 25, 2018
Expanding Evaporation Rate Model Determination of Hand-Rub Sanitizers to the General Freshman and Engineering Chemistry Undergraduate Laboratory: Inquiry-Based Formulations, Viscosity Measurements, and Qualitative Biological Evaluations
Additions to the popular evaporation rate determination laboratory of alcohol-based hand-rub sanitizers are described here. Significantly, inquiry-driven protocols for formulating hand-rub sanitizers, falling-ball viscometry, and sanitizer efficacy are included. Incorporation of familiar substances (“molecular relevance”) enables students to assimilate knowledge and connect to and recognize interrelated disciplines.

2018 Publications

Journal of Cheminformatics

Key features and updates for Origin 2018

OriginLab’s newest version update to Origin and OriginPro includes ease-of-use features, like Origin Central updates and creation of an App Center, as well as larger changes like the addition of Unicode charac...

James G. Moberly, Matthew T. Bernards and Kristopher V. Waynant

Journal of Cheminformatics 2018 10:5

Published on: 9 February 2018

2017 Publications  

European Journal of Inorganic Chemistry

DOI: 10.1002/ejic.201701097

Deconvoluting the Innocent vs. Non-Innocent Behavior of N,N-diethylthioformamide Ligands with Copper Sources

Nicolas A. Johnson, Samuel R. Wolfe, Human Kabir, Gabriel A. Andrade, Glenn P.A. Yap, Zachariah M. Heiden, James G. Moberly, Mark F. Roll, and Kristopher V. Waynant

Experimental and computational investigation of reactions involving the redox-active arylazothioformamide ligand with multiple Cu(I) sources is described. Cu(I) halides produce dimeric 1:1 coordination species, while non-coordinating counter ions (BF4 and PF6) gave 2:1 species. Computational comparisons of bond length and angles suggest that the Cu atom remains in the +1 oxidation state.

Journal of Chemical Education

DOI: 10.1021/acs.jchemed.7b00440

UV–Vis Spectrophotometric Analysis and Quantification of Glyphosate for an Interdisciplinary Undergraduate Laboratory

Daniel E. Felton, Martina Ederer, Timothy Steffens, Patricia L. Hartzell and Kristopher V. Waynant

A simple assay to quantify glyphosate concentrations in environmental samples was developed as part of an interdisciplinary effort linking introductory laboratory courses in chemistry, biology, and microbiology.  Regression analysis indicated that the assay is linear up to 20.0 ppm, making it particularly useful for detection of low levels of glyphosate in environmental samples. The assay can be used to quantify the activity of glyphosate-degrading soil microorganisms by comparing glyphosate levels between autoclaved and nonautoclaved soil slurries.

Polymers for Advanced Technologies 
DOI: 10.1002/pat.3861
Volume 28, Issue 1, pgs 73-79.
Qualitative degradation of the pesticide coumaphos in solution, controlled aerosol, and solid phases on quaternary ammonium fluoride polymer brushes (pages 73–79)

Kristopher V. Waynant, Hyung-Jun Koo, Chunjie Zhang and Paul V. Braun

Version of Record online: 6 JUL 2016 | DOI: 10.1002/pat.3861

Quaternary ammonium fluoride polymer brush thin-film surfaces synthesized from surface-initiated atom transfer radical polymerization and post-polymerization modification proved capable of degrading the known pesticide coumaphos. Coumaphos degradation was visualized through detection of known fluorescent by-product chlorferon. Brush surfaces allow for various pesticide delivery methods and could prove useful for detection and degradation of pesticides and chemical threats.

2013-2016 Publications as part of UIUC team:

Hyung-Jun Koo, Kristopher V Waynant, Chunjie Zhang, Richard T Haasch, Paul V Braun

Chemistry of Materials 2014, 26(8) 2678-2683

We report a general diffusion based method to form micrometer-scale lateral chemical
gradients in polymer brushes via selective alkylation. A quaternized brush gradient is
derived from a concentration gradient of alkylating agent formed by diffusion in permeable
media around a microchannel carrying the alkylating agent. Polymer brushes containing
both charge and aromatic gradients are formed using the alkylating agents, methyl iodide
and benzyl bromide, respectively. The gradients are quantitatively characterized by ...

Hyung-Jun Koo, Kristopher V Waynant, Chunjie Zhang, Paul V Braun

ACS applied materials & interfaces 2014 6(16) 14320-14326

We present a facile microfluidic method for forming narrow chemical gradients in polymer
brushes. Co-flow of an alkylating agent solution and a neat solvent in a microfluidic channel
forms a diffusion-driven concentration gradient, and thus a gradient in reaction rate at the
interface of the two flows, leading to a quaternization gradient in the underlying poly (2-
(dimethylamino) ethyl methacrylate) polymer brush. The spatial distribution of the
quaternized polymer brush is characterized by confocal Raman microscopy. The ...

Chunjie Zhang, Amit Sitt, Hyung-Jun Koo, Kristopher V Waynant, Henry Hess, Brian D Pate, Paul V Braun

Journal of the American Chemical Society 2015, 137(15) 5066-5073

Materials which induce molecular motion without external input offer unique opportunities for
spatial manipulation of molecules. Here, we present the use of polyacrylamide hydrogel
films containing built-in chemical gradients (enthalpic gradients) to direct molecular
transport. Using a cationic tertiary amine gradient, anionic molecules were directionally
transported up to several millimeters. A 40-fold concentration of anionic molecules dosed in
aerosol form on a substrate to a small region at the center of a radially symmetric cationic ...

2010-2013 Publications 

Synthesis of β-C-GlcNAc Ser from β-C-Glc Ser

EG Nolen, L Li, KV Waynant
The Journal of organic chemistry 78 (13), 6798-6801

Enhanced shape-selective recognition of anion guests through complexation-induced organization of porphyrin hosts

MJ Wienkers, J Ramos, H Jemal, C Cardenas, P Wiget, A Nelson, S Free, ...
Organic letters 14 (6), 1370-1373

Synthesis of hydronaphthalenes through coupling of enyne-carbonyl compounds that contain pendant alkane groups with Fischer carbene complexes
RK Patti, S Duan, A Camacho-Davila, K Waynant, KA Dunn, JW Herndon
Tetrahedron letters 51 (28), 3682-3684

Publications before 2008